Product name:BACLOFEN (BACLOFEN) FOR YOUR NHS PRESCRIPTION
Company name:
DIN:01342409
Status:Marketed
Status date:2001-08-10
| Active ingredient(s) | Strength |
|---|---|
| BACLOFEN (BACLOFEN) | 10 MG |
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For consumers| Resource | Description |
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The Product Monograph is a scientific document that describes the properties, claims, indications and conditions of use of the product and contains any other information that may be required for optimal, safe and effective use. The Product Monograph includes three sections:
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Side effects are troublesome symptoms or feelings that you may not expect that show up when you are taking a medicine. All suspected side effects should be reported, especially those that are:
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Section C.01.020.1 of the Food and Drug Regulations and section 62 of the Medical Devices Regulations, require hospitals to report to Health Canada all serious adverse drug reactions (ADRs) and medical device incidents (MDIs) within 30 days of being documented within the hospital. This regulatory requirement only applies to hospitals. |
| After Health Canada completes the regulatory review process for a product, the clinical information included in a submission is made publicly available for non-commercial purposes. |
The use of baclofen for muscle spasticity is associated with a poor prognosis. A retrospective analysis of 30,000 patients with severe spasticity (i.e., multiple sclerosis) treated with oral baclofen for a minimum of 2 years showed a median survival of 3.5 years. There was also an increase in mortality with a median survival of 5.8 years, compared to 2.8 years for the placebo group. The use of baclofen was associated with an increased risk of multiple system organ failure. Patients with severe spasticity treated with baclofen had a higher incidence of death than placebo patients. The use of baclofen in these patients had a significantly higher incidence of hospitalisation, including death, in the baclofen group compared to the placebo group. It is important to note that patients who received baclofen treatment for muscle spasticity should be monitored for signs of renal impairment and should be given close monitoring during treatment. In patients with moderate spasticity, baclofen is not recommended as first-line treatment for patients with muscle spasticity who have poor renal function, as there may be an increased risk of renal impairment. In this population, baclofen may be preferred in patients with severe spasticity who have poor renal function. It should be taken into account that patients with severe spasticity who are treated with baclofen may have an increased risk of developing acute renal failure, which may be life-threatening.
Figure 1. The effect of baclofen on multiple system organ failure in patients with severe spasticityBaclofen is widely used as an oral treatment for muscle spasticity, but it is associated with a risk of multiple system organ failure. The risk of multiple system organ failure in patients treated with baclofen has been shown to be increased with longer duration of treatment, but is generally higher in the elderly (50 years), in patients with renal impairment (creatinine clearance (CrCl) <30 mL/min), and in patients with diabetes mellitus (diabetes duration <12 years). The increased risk of multiple system organ failure may also be seen in patients receiving baclofen treatment, especially those with a CrCl <30 mL/min (see ).
The use of baclofen has been associated with a risk of a range of adverse events including hypotension, bradycardia, myoclonus, muscle cramping, and headache. The increased risk of multiple system organ failure is also known to be increased with longer duration of treatment. A review of the literature suggests that in these patients, baclofen may be used for longer periods of time, however, the risk of multiple system organ failure is increased with longer treatment duration and higher doses of baclofen.
The combination of baclofen and metoprolol, a centrally acting inhibitor of skeletal muscle spasm, has been shown to reduce the risk of multiple system organ failure in patients with multiple sclerosis. However, it has been shown to have a different effect on the skeletal muscle. Patients treated with baclofen who have a CrCl <30 mL/min (CrCl 30-40 mL/min) have a lower incidence of death than patients treated with metoprolol (CrCl 30-40 mL/min). This suggests that caution should be taken when prescribing baclofen, particularly in the first few months of treatment, particularly in patients with severe spasticity. Further research is needed to determine the clinical significance of this finding, as well as the relationship of baclofen and multiple system organ failure to other health conditions. If the use of baclofen is continued despite the risk of multiple system organ failure, monitoring and management of the patient should be started accordingly.
The use of baclofen has been associated with an increased risk of hospitalisations in patients with severe spasticity. The use of baclofen has been associated with a risk of multiple system organ failure, and this has been observed in patients receiving a combination of metoprolol and baclofen. In patients with severe spasticity, the use of baclofen may be recommended if renal function is poor, and the patient has an increased risk of multiple system organ failure. However, the risk of multiple system organ failure is increased with longer treatment duration and higher doses of baclofen.
The use of baclofen has also been associated with an increased risk of multiple system organ failure in patients receiving a combination of metoprolol and baclofen.
Baclofen Tablets, 10 mg / 10 mg Dose
is a drug which helps with the control of muscle spasms and stiffness in people with various medical conditions and/or diseases. Baclofen helps in reducing the pain and spasms which occur during the movement of a person. Baclofen tablet is usually taken on the third or fourth day of the menstrual cycle. It is recommended to take it after meals. In case you forget to take it, you may skip the dose. Take it only as prescribed by your doctor. In case, you take it every day, it should be taken at the same time of the day as it is normally used. This medicine may be taken with or without food, but you should take it under the supervision of your doctor as it can affect the metabolism of the medicine. In case, you take it on a regular basis, it will be easier for you to take it. You should take it at the same time every day. Take it as advised by your doctor. Never take more than the recommended dose. If it is almost time for your next dose, skip the dose and take the next dose at the usual time.
If you miss the dose, take it as soon as possible.
Take it as directed by your doctor. Dosage and usage are prescribed by your doctor. Take it exactly as your doctor has told you. Do not take more or less of it or take it more often than prescribed by your doctor. Do not stop taking it without consulting your doctor.
You should always keep the medicine in an upright position and avoid lying down. Avoid driving if you feel dizzy or if you feel sick.
Some of the common side effects of Baclofen tablets are listed below. These side effects may happen in some people. They usually go away on their own after a while. If they do not go away after a while, talk to your doctor.
Some of the more severe side effects of Baclofen tablets include:
If any of these severe side effects of Baclofen tablets are experienced, it is important to seek medical attention immediately.
Before taking Baclofen, tell your doctor about your medical history. You should also tell the doctor about any allergies or other medical conditions you have. In case, you have any other medical conditions that may be affected by Baclofen tablets, you should contact your doctor before you start taking it.
Some of the side effects of Baclofen tablets are listed below.
If any of these side effects of Baclofen tablets are experienced, it is important to seek medical attention immediately.
You should also tell the doctor about any other medications you are taking. In case, you have any other medical conditions that may affect the medicine, you should consult your doctor.
In case you are already taking any medicines, you should tell your doctor. There may be interactions between Baclofen and certain drugs. Some drugs may interact with the medicines they are prescribed for. Before you take any medicine, you should tell your doctor about any allergies, any other medical conditions, or any other medicines you are already taking.
Generic name: Baclofen (Lioresal)
Brand name: Baclofen
Baclofen is used to treat muscle spasms in the following conditions:
Each person may react differently to Baclofen. Some people may react differently to Baclofen, and some may react differently to other medications. If you think you may be experiencing some side effects of Baclofen contact your doctor or seek medical attention right away. Baclofen may cause side effects, although not everyone will react differently to it.
This medicine is not addictive. You will not be able to have or maintain an erection or maintain one without the help of this medicine.
Baclofen belongs to a group of medicines called GABA-B agonists. Baclofen works by blocking the release of certain chemicals in the brain that cause muscle spasms.
The muscle spasms may last for up to 4 hours. This is why you will not be able to have or maintain an erection or maintain one without the help of this medicine.
Some people may not be able to have or maintain an erection or maintain one with the help of this medicine.
Some people may have side effects while taking Baclofen. Some side effects may include:
If you think you may have any side effects, talk to your doctor or pharmacist. Some side effects may be less likely to occur if you are taking Baclofen. However, you will still be able to have or maintain an erection and maintain one without the help of this medicine.
If you are experiencing side effects while taking Baclofen contact your doctor or seek medical attention right away. If you think you may have some side effects, talk to your doctor or pharmacist.
It is a muscle relaxant. It is used to help relieve muscle pain, tightness, spasms and stiffness. It is also used to reduce the frequency and severity of muscle weakness.
Baclofen is a muscle relaxant. It helps to reduce muscle stiffness and spasms. It relaxes the muscles that cause muscle weakness. This medicine is used to treat muscle pain, tightness, and stiffness caused by spasms, spasms, or muscle spasms.
Baclofen is an anti-seizure medicine. It relaxes muscles, improves blood flow to the brain, relieves pain and reduces stiffness. It reduces the spasticity caused by the multiple sclerosis (MS) spinal cord injury.
It also reduces the frequency and severity of muscle weakness.
Stade de France Pharmacy